Direct detection of multidrug-resistant Mycobacterium tuberculosis in clinical specimens in low- and high-incidence countries by line probe assay.

نویسندگان

  • Isik Somuncu Johansen
  • Bettina Lundgren
  • Anaida Sosnovskaja
  • Vibeke Østergaard Thomsen
چکیده

The INNO-LiPA Rif.TB assay is designed for the detection of rpoB gene mutations causing rifampin resistance in isolates. We applied the method directly to 60 Lithuanian and Danish clinical specimens to detect rifampin resistance rapidly. Results were obtained in 78.3% of clinical specimens, and all were concordant with those obtained by BACTEC 460. The assay could have major impact on the management of multidrug-resistant tuberculosis.

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عنوان ژورنال:
  • Journal of clinical microbiology

دوره 41 9  شماره 

صفحات  -

تاریخ انتشار 2003